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1

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors

Tatsuzo Ukita, Yoshinori Nakamura, Akira Kubo, Yasuo Yamamoto, Yasunori Moritani, Kunio Saruta, Takanori Higashijima, Jun Kotera, Kotomi Fujishige, Michino Takagi, Kohei Kikkawa, Kenji Omori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

2

A synthesis of 1-pyridylnaphthalene lignan analogs

Masakatsu Sugahara, Yasunori Moritani, Yoshihiro Terakawa, Tsuyoshi Ogiku, Tatsuzo Ukita, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 283 KB

english, 1998

3

Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors

Tatsuzo Ukita, Masakatsu Sugahara, Yoshihiro Terakawa, Tooru Kuroda, Kazuteru Wada, Aya Nakata, Hideo Kikkawa, Katsuo Ikezawa, Kazuaki Naito

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

4

Monitoring of Solvent-Mediated Polymorphic Transitions Using in Situ Analysis Tools

Kobayashi, Ryo, Fujimaki, Yasuto, Ukita, Tatsuzo, Hiyama, Yukio

Journal:

Organic Process Research & Development

Year:

2006

Language:

english

File:

PDF, 786 KB

english, 2006

5

ChemInform Abstract: An Efficient Synthesis of the Antiasthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.

Masakatsu Sugahara, Yasunori Moritani, Tooru Kuroda, Kazuhiko Kondo, Hideshi Shimadzu, Tatsuzo Ukita

Journal:

Year:

2000

File:

PDF, 31 KB

2000

6

Chemical Studies on Tuberactinomycin. XIV. Novel Synthesis of DL-Capreomycidine

Wakamiya, Tateaki, Mizuno, Katsutoshi, Ukita, Tatsuzo, Teshima, Tadashi, Shiba, Tetsuo

Journal:

Bulletin of the Chemical Society of Japan

Year:

1978

File:

PDF, 801 KB

1978

7

The first synthesis of (�)-cycloolivil: a highly stereoselective synthesis of 3-hydroxy-1-aryltetralin lignans based on the stereoselective hydroxylation of ?,?-dibenzyl-?-butyrolactones

Moritani, Yasunori, Ukita, Tatsuzo, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1995

Language:

english

File:

PDF, 223 KB

english, 1995

8

ChemInform Abstract: Synthetic and Mechanistic Study of the Acid-Promoted Aromatization of the Diels—Alder Adduct: 6,7-Dimethoxy-1- (4-pyridyl)-1,4-epoxytetrahydronaphthalene-2,3-dicarboxylate.

Masakatsu Sugahara, Yasunori Moritani, Tooru Kuroda, Kazuhiko Kondo, Tatsuzo Ukita

Journal:

Year:

2002

File:

PDF, 35 KB

2002

9

Stereoselective syntheses of E- and Z-9,11-dodecadien-1-yl acetates: The major sex pheromones of the red bollworm moth.

OCHIAI, MASAHITO, UKITA, TATSUZO, FUJITA, EIICHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1983

File:

PDF, 673 KB

1983

10

Construction of Heterocyclic Compounds by Use of α-Diazophosphonates: New One-Pot Syntheses of Indoles and Isocoumarins

Nakamura, Yoshinori, Ukita, Tatsuzo

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 49 KB

english, 2002

11

A new synthesis of olefins via the elimination reaction of .BETA.-tributylstannyl organosulfur compounds.

OCHIAI, MASAHITO, UKITA, TATSUZO, FUJITA, EIICHI, TADA, SHINICHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1984

File:

PDF, 1.08 MB

1984

12

Total synthesis of L-capreomycidine

Tetsuo Shiba, Tatsuzo Ukita, Katsutoshi Mizuno, Tadashi Teshima, Tateaki Wakamiya

Journal:

Tetrahedron Letters

Year:

1977

Language:

english

File:

PDF, 221 KB

english, 1977

13

ChemInform Abstract: Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives.

Tatsuzo Ukita, et al. et al.

Journal:

Year:

2001

File:

PDF, 29 KB

2001

14

1,7- and 2,7-Naphthyridine Derivatives as Potent and Highly Specific PDE5 Inhibitors.

Tatsuzo Ukita, et al. et al.

Journal:

Year:

2003

File:

PDF, 143 KB

2003

15

A synthesis of α-substituted trans-α, β-dibenzyl-γ-butyrolactones: diastereofacial differentiation in the electrophilic attack on the metal enolates of α, β-dibenzyl-γ-butyrolactones

Moritani Yasunori, Ukita Tatsuzo, Nishitani Takashi, Seki Masahiko, Iwasaki Tameo

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 261 KB

english, 1990

16

Desulfonation of vinyl sulfones utilizing .BETA.-elimination of .BETA.-stannyl organosulfur compounds.

OCHIAI, Masahito, UKITA, Tatsuzo, NAGAO, Yoshimitsu, FUJITA, Eiichi

Journal:

NIPPON KAGAKU KAISHI

Year:

1985

File:

PDF, 2.16 MB

1985

17

Novel, Potent, and Selective Phosphodiesterase-4 Inhibitors as Antiasthmatic Agents: Synthesis and Biological Activities of a Series of 1-Pyridylnaphthalene Derivatives

Ukita, Tatsuzo, Sugahara, Masakatsu, Terakawa, Yoshihiro, Kuroda, Tooru, Wada, Kazuteru, Nakata, Aya, Ohmachi, Yasushi, Kikkawa, Hideo, Ikezawa, Katsuo, Naito, Kazuaki

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 347 KB

english, 1999

18

Effect of silica gel on the benzenesulfinic acid catalyzed isomerization of vinylsilanes. Formation of silyl benzenesulfinate

Ochiai, Masahito, Takaoka, Yoshikazu, Ukita, Tatsuzo, Nagao, Yoshimitsu, Fujita, Eiichi

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 638 KB

english, 1989

19

A highly stereoselective synthesis of α-substituted cis-α, β-dibenzyl-γ-butyrolactones

Yasunori Moritani, Chiaki Fukushima, Tsuyoshi Ogiku, Tatsuzo Ukita, Toshikazu Miyagishima, Tameo Iwasaki

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 259 KB

english, 1993

20

Stereoselective Syntheses of Cis - and Trans -Isomers of α-Hydroxy-α,β-dibenzyl-γ-butyrolactone Lignans: New Syntheses of (±)-Trachelogenin and (±)-Guayadequiol

Moritani, Yasunori, Fukushima, Chiaki, Ukita, Tatsuzo, Miyagishima, Toshikazu, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 397 KB

english, 1996

21

A NEW STEREOSELECTIVE SYNTHESIS OF VINYLSILANES UTILIZING VINYL SULFONES

Ochiai, Masahito, Ukita, Tatsuzo, Fujita, Eiichi

Journal:

Chemistry Letters

Year:

1983

Language:

english

File:

PDF, 3.54 MB

english, 1983

22

Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives

Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Moritani, Yasunori, Saruta, Kunio, Higashijima, Takanori, Kotera, Jun, Takagi, Michino, Kikkawa, Kohei, Omori, Kenji

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 316 KB

english, 2001

23

Construction of Heterocyclic Compounds by Use of α-Diazophosphonates: New One-Pot Syntheses of Indoles and Isocoumarins.

Yoshinori Nakamura, Tatsuzo Ukita

Journal:

Year:

2002

File:

PDF, 34 KB

2002

24

Synthesis and Biological Activities of 1-Pyridylisoquinoline and 1-Pyridyldihydroisoquinoline Derivatives as PDE4 Inhibitors.

Tatsuzo Ukita, Masakatsu Sugahara, Yoshihiro Terakawa, Tooru Kuroda, Kazuteru Wada, Aya Nakata, Hideo Kikkawa, Katsuo Ikezawa, Kazuaki Naito

Journal:

Year:

2003

Language:

english

File:

PDF, 131 KB

english, 2003

25

Hypervalent Organoiodine-Promoted Oxidative Ring Expansions of Tributylstannyl Lactols. New and General Synthesis of Unsaturated Medium-Ring Lactones

Ochiai, Masahito, Iwaki, Shigeru, Ukita, Tatsuzo, Nagao, Yoshimitsu

Journal:

Chemistry Letters

Year:

1987

Language:

english

File:

PDF, 7.63 MB

english, 1987

26

1-Arylnaphthalene Lignan: A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor

Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Takahashi, Masami, Kotera, Jun, Ikeo, Tomohiro

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

27

Synthetic and mechanistic study of the acid-promoted aromatisation of the Diels–Alder adduct: 6,7-dimethoxy-1-(4-pyridyl)-1,4-epoxytetrahydronaphthalene-2,3-dicarboxylate

Sugahara, Masakatsu, Moritani, Yasunori, Kuroda, Tooru, Kondo, Kazuhiko, Ukita, Tatsuzo

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

28

1,4-Fragmentatioin of ?-tributylstannyl alcohols by a hypervalent organoiodine compound: a new synthesis of unsaturated carbonyl compounds

Ochiai, Masahito, Ukita, Tatsuzo, Nagao, Yoshimitsu, Fujita, Eiichi

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1984

Language:

english

File:

PDF, 166 KB

english, 1984

29

Oxidative Grob fragmentation of .gamma.-tributylstannyl alcohols with a combination of iodosylbenzene, dicyclohexylcarbodiimide, and boron trifluoride

Ochiai, Masahito, Ukita, Tatsuzo, Iwaki, Shigeru, Nagao, Yoshimitsu, Fujita, Eiichi

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 1.25 MB

english, 1989

30

Total Syntheses of (2 S )-Antafumicins A and B

Fujimoto, Yuzo, Ukita, Tatsuzo, Miyagawa, Hisashi, Tsurushima, Tetsu, Irie, Hiroshi, Nishimura, Keiichiro, Ueno, Tamio

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1994

Language:

english

File:

PDF, 821 KB

english, 1994

31

An Efficient Synthesis of the Anti-asthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.

SUGAHARA, Masakatsu, MORITANI, Yasunori, KURODA, Tooru, KONDO, Kazuhiko, SHIMADZU, Hideshi, UKITA, Tatsuzo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2000

File:

PDF, 564 KB

2000

32

A new desulphonylation of ?,?-unsaturated sulphones via conjugate addition of tributylstannyl-lithium

Ochiai, Masahito, Ukita, Tatsuzo, Fujita, Eiichi

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1983

Language:

english

File:

PDF, 157 KB

english, 1983

33

A highly stereoselective synthesis of 3-hydroxy-1-aryltetralin lignans based on the stereoselective hydroxylation of ?,?-dibenzyl-?-butyro-lactones: the first synthesis of (�)-cycloolivil

Moritani, Yasunori, Ukita, Tatsuzo, Hiramatsu, Hajime, Okamura, Kimio, Ohmizu, Hiroshi, Iwasaki, Tameo

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 1.02 MB

english, 1996

34

Intramolecular hypervalent tin-oxygen interaction. The origin for fixation of six-membered carbocycles to the 1,3-diaxial conformer and for stereoselective osmylations

Ochiai, Masahito., Iwaki, Shigeru., Ukita, Tatsuzo., Matsuura, Yoshiki., Shiro, Motoo., Nagao, Yoshimitsu.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 1.20 MB

english, 1988

35

Stereochemistry of an oxidative 1,4-fragmentation of ?-stannyl alcohols with a hypervalent organoiodine compound and the synthesis of erythro-6-acetoxyhexadecan-5-olide

Ochiai, Masahito, Ukita, Tatsuzo, Nagao, Yoshimitsu, Fujita, Eiichi

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1985

Language:

english

File:

PDF, 217 KB

english, 1985

36

A Facile Copper-Catalyzed Ullmann Condensation: N-Arylation of Heterocyclic Compounds Containing an -NHCO- Moiety.

SUGHARA, Masakatsu, UKITA, Tatsuzo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1997

File:

PDF, 484 KB

1997

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